INTRODUCTION TO TECHNOLOGY BreathLab

Our breath technology BreathLab is based on METABOLOMICS, a completely new science with enormous potential that is based on the study of organic molecules called Metabolites, present in a biological system.

This branch of the study of human breath is characterized by offering a method:

  • Simple.
  • Quick.
  • Portable.
  • Relatively economic.
  • Non-invasive.
  • It gives highly sensitive results.

Our interest is to be able to position ourselves as the first step in the clinical diagnosis ladder as a simple and economical system of POPULATION SCREENING.

How does it work?

1

Following a simple protocol, we collected the patient's sample in a Breath-collecting Bag.

2

We captured 400 ml of breath and transferred it to our laboratory as soon as possible for evaluation.

3

We connected the Exhalado Breath Collection Bag to the Laninose 43 equipment to evaluate the METABOLITES present in the sample.

4

The Volatile Organic Compounds (VOCs) present in the Exhaled Breath are adsobidos causing an increase in the electrical resistance of 32 Nanosensors and generates a SPECIFIC DIGITAL FOOTPRINT (BreathPrint) caused by the differences captured in each chemoreceptor. His sensitivity is Part by Million.

5

The data collected is evaluated with a complex Algorithm to perform a Linear Discriminant Canonical Analysis demonstrating a significant difference between groups of Patients qualified as Positive and Negative. An analysis of curves is performed as a statistical method to determine the diagnostic accuracy of the chemical fingerprint, determining Sensitivity, Specificity and Discriminative Capacity of Diagnosis, that is, the DIFFERENTIAL CAPACITY of subjects HEALTHY VERSE SICK. The sensitivity of our method allows us to offer results with a NEGATIVE PREDICTIVE VALUE of 99.5%

6

A Report with the results of the Patient is automatically processed and sent via WhatsApp or Email to the corresponding person.

7

NEGATIVE RESULT: LOW RISK, congratulations! Your breath sample indicates that we DO NOT FIND ELEMENTS TO INDICATE THAT THERE ARE MOLECULES OF CANCER.

POSITIVE RESULT: The study of your breath indicates that there is HIGH RISK when finding a sufficient quantity of abnormal molecules present in the sample.

Fundamentals of olfactory technology

The electronic noses are considered an easy-to-apply, practical and non-invasive analysis technique designed to determine, recognize and identify very low levels of volatile biochemicals, called Volatile Organic Compounds (VOCs).

Its principle is based on the configuration of electrobiochemical sensors that create a unique fingerprint of a patient's breath sample, making possible the quality control, characterization, classification and differentiation of VOCs, which can be identified by functional groups through multivariate statistical analysis techniques, which guarantee their usefulness in different applications of clinical diagnosis.

A scent emanating from a patient's breath is a combination of hundreds of biochemical substances with unique characteristics. An electronic nose consists of an analytical instrument that tries to emulate the process of identification of aromas by means of the construction of electronic systems of smell, since they offer a fast, safe and reliable alternative with technical and economic advantages compared to other procedures such as gas chromatography. or sensory analysis.

An electronic smell system is formed by three main elements:
* A measurement system composed of an aroma extraction technique or air flow system that transports the VOCs of the samples to an array of biochemical sensors that transform the information received into electrical signals

*A system for extracting the characteristic features of the sample analyzed by quantifying and transforming data from the signals of the different sensors.

*A pattern recognition system to identify and classify the aroma of the measured samples. The purpose of combining an array of sensors is to provide a global signal called "fingerprint" as the simple response of a characteristic aroma of the sample.

The sensors integrated into the electronic nose must meet the following criteria:

*High sensitivity for the detection of VOCs.
*Low sensitivity to humidity and temperature.
*High reproducibility and stability with short reaction time and easy calibration.

Each sensor will give a conductivity value, obtaining at the end a data matrix of "m" columns by "n" rows, where the columns will be the number of sensors that have the nose and "n" the number of samples. The results are therefore analyzed with multivariate statistical analysis techniques.

Once the signals from the electronic nose sensors have been obtained, it is necessary to implement data processing techniques to interpret them according to the application to be evaluated. The proper use of pattern recognition techniques ensures that the signals from the sensors can be analyzed to build reliable models for either prediction, detection, identification or classification.


FUTURE OF TECHNOLOGY BreathLab

The BreathLab limit is subject to the limit of our imagination. Thanks to this technology we will be able to detect in the future:

Tel: +52(33) 3631-2080
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