History

The ancient Greeks knew that certain exhaled odors could be associated with diseases, however, it is until now that the analysis of the breath is generating confidence and credibility in the world medical community thanks to its wide range of applications and benefits.

The modern study of the breath arises in the year 1971 when the Nobel Prize for Medicine Dr. Linus Pauling manages to separate components of the breath through a new technique called "Gas Chromatography", which indicated that the human breath is a set of more than 250 Volatile Organic Compounds -VOCs- in picomolar concentrations.

In the 90s it was found that the smell of bloodhounds is up to 200 times more sensitive than human smell and is able to detect cancer in patients.

The arrival of the new millennium incorporated the technology of "microchips" that allowed the manufacture of smaller and more sensitive equipment, in recent years, the incorporation of nanotechnology, sensors, data management via Bluetooth and Wi-Fi allow us to combine everything previous to consolidate us as pioneers in this new medical branch: THE METABOLOMIC.

Dr. Linus Pauling discovers the "Gas Chromatography".

The smell of bloodhounds is up to 200 times more sensitive than human smell.

Principle of the test

THE GASEOUS EXCHANGE

When breathing, we inhale oxygen and exhale carbon dioxide, generating an exchange of gases between the pulmonary alveoli and the blood. If there is any type of tumor in the patient's body, the tumor molecules detach and travel through the bloodstream. When the blood reaches the lungs for oxygenation, gaseous exchange occurs in the alveoli, due to the concentration of gases inside and outside of the lungs, producing an exchange between the blood and the alveolar air.


What concerns us is the exhaled CO2, since it becomes a means of transport of Metabolites. Now, oxidative stress is a biochemical situation of imbalance between free radicals and antioxidant defense mechanisms. Cancer is per se a disease that induces oxidative stress. Alterations of neoplastic cells and tumor infiltration by inflammatory cells CAN BE DETECTED IN THE BREATH.

Depending on the type of cancer, each type of tumor releases different types of TOTALLY DIFFERENT cells and each pathology emits different Volatile Organic Compounds, that is, a DIFFERENT ODOR, which is why we can clearly differentiate a breath sample with breast cancer against a shows with lung cancer, etc.

These compounds come in concentrations of PARTS PER MILLION and can only be detected with highly sensitive equipment such as our Electronic Nose: LabiNose 43.

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